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KMID : 0861020210360050109
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Korea Journal of Herbology
2021 Volume.36 No. 5 p.109 ~ p.115
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Single Oral Dose Toxicity Test of Coix lacryma-jobi var. ma-yuen Stapf Sproutin Sprague-Dawley Rats
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Kim Min-Ju
Lee Jeong-Hoon
Shin Mi-Rae
Roh Seong-Soo
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Abstract
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Objectives : ‘Johyun’ yulmoo which is a new variety of Coix lacryma-jobi var. ma-yuen Stapf sprout was developed and registered by Rural development administration in 2004. This variety was derived from the cross between single cross of Suwon-6 and Okayama and UCN300-25 as F1. It is characterized by early maturity, short plant height, a strong resistance, and a superior yield and is suitable for the central and northern regions. Accordingly, we were performed and evaluated single oral dose toxicity test of ‘Johyun’ yulmoo sprout (JYS) in Sprague-Dawley (SD) rats.
Methods : Single oral dose toxicity test was performed using with male and female rats. Rats were divided into two groups: Group 1, vehicle-treated rats (Control); Group 2, JYS 5000 mg/kg-treated rats. JYS was orally administered to male and female rats at dose levels of 5000 mg/kg. Animals were monitored on the mortality, clinical signs, body weight changes, and necropsy findings for 14 days. groups : Group 1, vehicle-treated rats (Control); Group 2, JYS 5000 mg/kg-treated rats. JYS was orally administered to male and female rats at dose levels of 5000 mg/kg. Animals were monitored on the mortality, clinical signs, body weight changes, and necropsy findings for 14 days.
Results : After oral treatment of JYS, we could not find any mortality at 5000 mg/kg. Compared with the control group, there were also no significant differences in clinical sign, weight changes, weight gain, and gross abnormalities in JYS 5000 mg/kg-treated group.
Conclusions : Taken together, these results suggest that approximate lethal dose of JYS was considered as over 5000 ㎎/㎏. Results from this study provide scientific evidence for the safety of JYS. Moreover, this study could be used as a basis for dose-setting data of the repeated dose 13-week oral toxicity test of JYS.
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KEYWORD
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Coix lacryma-jobi var. ma-yuen Stapf, Johyun yulmoo sprout, single oral dose toxicity, SD rats
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